Women's Health Weekly
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Bone Loss
Thrombospondin-2 loss modeled, effect on ovariectomy-induced bone loss revealed
October 6th, 2005
According to recent research from the United States published in the journal Matrix Biology, increased osteoblastogenesis and decreased bone resorption protect against ovariectomy (OVX)-induced bone loss in thrombospondin-2 (TSP-2)-null mice. "Although bone is composed primarily of extracellular matrix (ECM), the dynamic role that the ECM plays in regulating bone remodeling secondary to estrogen loss is relatively unexplored. "Previous studies have shown that mice deficient in the matricellular protein TSP2 form excess endocortical bone; thus, we postulated that enhanced bone formation in TSP2-null mice could protect against OVX-induced bone...
Source: Women's Health Weekly (2005-10-06)
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