Women's Health Weekly
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Breast Cancer
Letrozole compared to endocrine therapy for breast cancer treatment
October 6th, 2005
Letrozole has been compared to endocrine therapy for breast cancer treatment in recent trials. "Endocrine therapy, predominantly using the antiestrogen tamoxifen, has long been a key treatment strategy for estrogen receptor-positive breast cancer," stated investigators in Denmark. "An alternative approach is to treat patients with aromatase inhibitors, which suppress estrogen biosynthesis." H. T. Mouridsen and colleagues explained, "Letrozole, and other third-generation aromatase inhibitors, are highly specific and potent inhibitors of estrogen production, which markedly reduce circulating estrogen levels and wholebody aromatisation of androgen...
Source: Women's Health Weekly (2005-10-06)
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