Women's Health Weekly
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Breast Cancer
Novel candidate oncogenes identified
October 6th, 2005
A 1Mb minimal amplicon at 8p11-12 has been used to identify novel candidate breast cancer oncogenes. "Amplification of 8p11-12 is a well-known alteration in human breast cancers, but the driving oncogene has not been identified," oncologists in England explained. In a recent study, M.J. Garcia and coauthors at the University of Cambridge "developed a high-resolution comparative genomic hybridization array covering 8p11-12 and analyzed 33 primary breast tumors, 20 primary ovarian tumors and 27 breast cancer cell lines." "Expression analysis of the genes in the region was carried out by using real-time quantitative PCR and/or...
Source: Women's Health Weekly (2005-10-06)
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