Women's Health Weekly
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Breast Cancer
Osteonectin expression inhibited MDA-MB-231 breast cancer cell metastasis
October 13th, 2005
Osteonectin expression was seen to inhibit MDA-MB-231 breast cancer cell metastasis. "Skeletal metastases occur with high incidence in patients with breast cancer and cause long-term skeletal morbidity. Osteonectin (SPARC, BM-40) is a bone matrix factor that is an in vitro chemoattractant for breast and prostate cancer cells," scientists in the United States reported. "Increased expression of osteonectin is found in malignant breast tumors. We infected MDA-231 breast cancer cells with an adenovirus expressing osteonectin to examine the role of osteonectin expression in breast cancer cells and its effect on metastasis, in particular to bone....
Source: Women's Health Weekly (2005-10-13)
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