Hypoxia
Perinecrotic regions of solid tumors have reduced HIF-1 alpha expression
Published in Women's Health Weekly, October 20th, 2005
According to recent research from Canada, "Hypoxia that develops in solid tumors stabilizes the hypoxia-inducible factor-1 alpha (HIF-1 alpha) subunit of the HIF-1 transcription factor, leading to up-regulation of dozens of hypoxia-regulated genes that increase glycolysis and oxygen delivery. HIF-1 alpha and its downstream target gene CA9 have both been used as surrogate hypoxia markers, and, in general, high expression predicts for a poor response to treatment."
"Combinations of hypoxia markers offer the opportunity to measure changes in...
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