Women's Health Weekly
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Breast Cancer
HIF-1 alpha overexpression predicts early breast cancer relapse
October 20th, 2005
Hypoxia-inducible factor-1 alpha overexpression predicts early breast cancer relapse. "Hypoxia-inducible factor-1 alpha (HIF-1 alpha) is a transcription factor that is involved in tumor growth and metastasis by regulating genes involved in response to hypoxia. "HIF-1 alpha protein overexpression has been shown in a variety of human cancers, but only 2 studies have documented the prognostic relevance of HIF-1 alpha expression in breast cancer," researchers in France report. "The aim of our study was to determine accurately the impact of HIF-1 alpha expression on prognosis in a large series (n=745) of unselected patients with...
Source: Women's Health Weekly (2005-10-20)
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