Women's Health Weekly
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Breast Cancer
Pharmacological telomerase inhibition sensitized resistant cells to chemotherapy
October 20th, 2005
Scientists suggested pharmacological telomerase inhibition could sensitize resistant cells to chemotherapy. According to recent research from Canada, "Effective strategies to reverse or prevent chemotherapeutic resistance are required before cancer therapies can be curative. Telomerase is the ribonucleoprotein responsible for de novo synthesis and maintenance of telomeres, and its activity is predominantly observed in cancer cells." "The telomerase enzyme has been successfully inhibited or inactivated to sensitize cells to cellular stresses; however, no studies have determined yet the effect of combining a pharmacological inhibitor of telomerase...
Source: Women's Health Weekly (2005-10-20)
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