Women's Health Weekly
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Breast Cancer Vaccine Development
Imiquimod acts as adjuvant of DNA breast cancer vaccine
October 20th, 2005
Imiquimod and S-27609 act as adjuvants of DNA vaccination in a transgenic murine model of HER2/neu-positive mammary carcinoma. According to recent research from Italy, "DNA vaccination against HER-2/neu is an effective way to induce an immune response able to oppose the spontaneous development of mammary tumors occurring in HER-2/neu transgenic mice. In this study, we have evaluated the potential of imiquimod and the analogue S-27609 as adjuvants of DNA vaccination against HER-2/neu in transgenic mice." "The association of a DNA vaccine encoding a portion of rat HER2/neu with either imiquimod or S-27609 was found to delay the development of...
Source: Women's Health Weekly (2005-10-20)
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