Women's Health Weekly
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Biosynthesis
Temporal and spatial expression of LRH-1 during embryogenesis suggest potential role in development
October 27th, 2005
Evidence suggests that the role of liver receptor homologue-1 in gonadal development is to initiate folliculogenesis and regulate estrogen biosynthesis within the ovary. According to a study from the United States, "Liver receptor homologue-1 (LRH-1), an orphan member of the nuclear receptor family highly expressed in adult mouse ovary, is closely related to steroidogenic factor 1 (SF-1), known to be important in gonadal formation. To analyze the potential role of LRH-1 in gonadal differentiation, we compared LRH-1 and SF-1 expression during mouse embryonic and postnatal development." "LRH-1 expression was first detected in the urogenital ridge...
Source: Women's Health Weekly (2005-10-27)
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