Women's Health Weekly
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Breast Cancer
IRF-1 exhibits tumor suppressor activities in breast cancer
October 27th, 2005
Interferon regulatory factor-1 exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis. According to recent research from the United States, "We have directly assessed the ability of interferon regulatory factor-1 (IRF-1) to act as a tumor suppressor gene in human breast cancer cells and explored whether this suppressor function is mechanistically conferred by affecting cell cycle transition, apoptosis and/or caspase activation. We have used a dual approach, measuring whether overexpression of wild-type IRF-1 or a dominant negative IRF-1 (dnIRF-1) produce opposing effects on breast cancer cell proliferation in...
Source: Women's Health Weekly (2005-10-27)
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