Women's Health Weekly
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Cancer Therapy
Pretreatment evaluation of drug metabolism genes predicts drug response
October 27th, 2005
Pretreatment evaluation of drug metabolism genes can help predict individual patient response to anticancer drugs. Scientists in the United States conducted a study "to evaluate associations between patient survival, pharmacokinetics, and drug metabolism-related genetic polymorphisms in patients receiving a combination chemotherapy regimen for breast cancer. A genotype association study was conducted on 85 chemotherapy-naive patients with metastatic or inflammatory breast cancer that were evaluated for an extended period after receiving standard-dose chemotherapy followed by high-dose cyclophosphamide, cisplatin, and carmustine. Blood pharmacokinetics were evaluated,...
Source: Women's Health Weekly (2005-10-27)
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