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Women's Health Weekly

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DNA Research



DNA repair gene polymorphisms analyzed by radiosensitivity and cancer incidence



October 27th, 2005

Microsatellite polymorphisms in DNA repair genes XRCC1, XRCC3 and XRCC5 in patients with gynecological tumors were analyzed according to late clinical radiosensitivity and cancer incidence.

"This study investigates the association of microsatellite polymorphisms in XRCC1, XRCC3 and XRCC5 with the development of late radiation-induced radiotherapy reactions and examines the correlation between these microsatellites and cancer incidence. Sixty-two women with cervical or endometrial cancer treated with radiotherapy were included in the study," investigators in Belgium report.

"According to the CTCAEv3.0 scale, 22 patients showed late adverse...


Source: Women's Health Weekly (2005-10-27)

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