Women's Health Weekly
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Doxorubicin
Cells respond differently to doxorubicin
October 27th, 2005
Cells respond differently to doxorubicin (DHA) due to a differential oxidative response. "Polyunsaturated fatty acids have been reported to enhance the cytotoxic activity of several anticancer drugs. In the present study, we observed that differential effect of DHA among cells on drug toxicity results from a differential oxidative response to DHA (a long-chain omega-3 polyunsaturated fatty acid) was cell-line selective, affecting MDA-MB-231 and MCF-7dox (a doxorubicin-resistant cell line) but not the parental MCF-7 cell line," scientists reported in the journal Free Radical Biology and Medicine. "DHA supplementation led to an increase in...
Source: Women's Health Weekly (2005-10-27)
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