Women's Health Weekly
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Genetic Research
MUC1 affects c-Src signaling in PyV MT-induced mammary tumorigenesis
October 27th, 2005
Scientists believe MUC1 affects c-Src signaling in PyV MT-induced mammary tumorigenesis. "MUC1 is an integral membrane mucin glycoprotein that is normally expressed on the apical surface of most simple, secretory epithelia and hematopoietic cells. Overexpression of aberrantly glycosylated MUC1 is a hallmark of many carcinomas including 90% of breast carcinomas," investigators in the United States reported. "MUC1 has been shown to bind to c-Src tyrosine kinase in vitro, whereby c-Src phosphorylates the MUC1 cytoplasmic domain at a YEKV motif. c-Src is an extensively studied nonreceptor tyrosine kinase implicated in mammary tumorigenesis," explained A....
Source: Women's Health Weekly (2005-10-27)
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