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Obstetrics

Hyperoxic premature lungs exhibit excess p53 and diminished VEGF

Published in Women's Health Weekly, November 3rd, 2005

Hyperoxic premature lungs exhibit excess p53 and diminished vascular endothelial growth factor (VEGF).

According to recent research published in the journal Pediatric Research, "hyperoxia is implicated in the pathogenesis of bronchopulmonary dysplasia (BPD), a chronic lung disease of premature infants. High levels of supplemental oxygen can result in microvascular endothelial cell death and may disrupt lung development."

"In postnatal animals, hyperoxia inhibits expression of VEGF, which is required for normal vascular development. A potential mechanism of oxygen effects on VEGF is induction of p53, a transcription factor that represses VEGF...

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