Women's Health Weekly
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Apoptosis
Thiophene analogues of kenpaullone marked as possible anticancer drugs
November 3rd, 2005
Thiophene analogues of kenpaullone were marked as possible anticancer drugs. According to recent research from France, "Thieno analogues of kenpaullone have been synthesized using an established method. We investigated the effect of five structural analogues of kenpaullone on vincristine sensitive and resistant MCF7 (human mammary adenocarcinoma) cells." "One analogue, 8-Bromo-6,11-dihydro-thermo-[3',2':2,3]azepino[4,5-b]indol-5(4H)-one (3a), showed an antiproliferative activity in the drug sensitive cell line that led to cell accumulation in G2/M phase. In addition, repression of cdk 1, a G2/M transition key regulator, as well as induction of p21...
Source: Women's Health Weekly (2005-11-03)
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