Women's Health Weekly
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Breast Cancer
Estrogen receptor-alpha regulates SOCS-3 expression in breast cancer cells
November 3rd, 2005
Estrogen receptor-alpha regulates SOCS-3 expression in breast cancer cells. According to a recent report from Sweden, "The suppressor of cytokine signaling (SOCS) protein family negatively regulates cytokine action. In this study, we investigated the effects of estrogen (E2) on SOCS-3 expression in T47D and MCF-7 human breast cancer cells." "Real-time PCR analysis of E2-treated T47D cells revealed a ligand and time-dependent increase in of SOCS-3 mRNA levels. Cloning of a 1.7 kb fragment of the human SOCS-3 5' flanking sequence, and subsequent analysis of potential transcription factor-binding sites identified an incomplete ERE motif located -1493 to...
Source: Women's Health Weekly (2005-11-03)
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