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Adverse Drug Reaction

Researchers warn pulmonary edema could be serious adverse reaction from thiazade diuretics

Published in Women's Health Weekly, November 3rd, 2005

Researchers warn that pulmonary edema could be a serious adverse reaction from thiazade diuretics.

"Noncardiogenic pulmonary edema is a rare but potentially life-threatening complication of hydrochlorothiazide therapy. Investigators from Canada "describe three patients who developed this serious adverse reaction."

S. R. Knowles and colleagues described the cases: "A 64-year-old woman developed dypsnea and hypotension within 60 minutes of taking a single dose of hydrochlorothiazide 25 mg. She was admitted to the critical care unit with acute respiratory failure and subsequent multiple-organ dysfunction."

The authors continued, "The...

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