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Women's Health Weekly

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Breast Cancer



Cyclin A is a good marker for breast cancer tumor proliferation and prognosis



November 10th, 2005

Cyclin A is a good marker for breast cancer tumor proliferation and prognosis.

According to recent research from Finland, "We wanted to study cyclin A as a marker for prognosis and chemotherapy response. A total of 283 women with metastatic breast cancer were initially enrolled in a randomized multicenter trial comparing docetaxel to sequential methotrexate-fluorouracil (MF) in advanced breast cancer after anthracycline failure."

"Paraffin-embedded blocks of the primary tumor were available for 96 patients (34%). The proportion of cells expressing cyclin A was determined by immunohistochemistry using a mouse monoclonal antibody to human cyclin A....


Source: Women's Health Weekly (2005-11-10)

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