Women's Health Weekly
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Breast Cancer
Hedgehog signaling pathway targeted in breast cancer therapy
November 10th, 2005
The Hedgehog (Hh) signaling pathway could be a potential target in breast cancer therapy. According to recent research from Japan, "The Hh signaling pathway, which is well conserved even in mammals and other vertebrate species, has long been known to direct growth and patterning during embryonic development. It has been shown that the Hh pathway also plays a critical role in mouse normal mammary gland development." "Namely, it has been shown that disruption of the Hh pathway-related genes such as Patched-1 and Gli2 leads to ductal dysplasias that closely resemble some hyperplasia of human breast. In addition, it has been reported that breast...
Source: Women's Health Weekly (2005-11-10)
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