Women's Health Weekly
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Cancer Genetics
Adjuvant radiotherapy increases survival among women with p53 gene alterations
November 10th, 2005
Adjuvant radiotherapy substantially increases survival in endometrioid endometrial carcinomas among women with p53 gene alterations. "P53 genetic alterations are associated with advanced stage and aggressive tumors in a variety of human malignancies." Researchers from the United States examined "p53 for genetic alterations to evaluate the association of these alterations with clinical outcome and response to adjuvant radiotherapy in endometrioid endometrial carcinomas." "p53 mutations in exons 2-11 were assessed in 59 endometrioid carcinomas by polymerase chain reaction-single-strand conformational polymorphism and sequence analysis," according to B....
Source: Women's Health Weekly (2005-11-10)
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