Women's Health Weekly
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Chemotherapy
Zoledronic acid and doxorubicin induced synergistic levels of apoptosis
November 10th, 2005
Zoledronic acid and doxorubicin induced synergistic levels of apoptosis in breast cancer cells in vitro. "The bisphosphonate zoledronic acid and the cytotoxic drug doxorubicin induce synergistic levels of apoptosis in breast cancer cells. As zoledronic acid and doxorubicin have been shown to reduce cell invasion and migration, we have investigated if these drugs also act synergistically on breast cancer invasion in vitro," scientists in England reported. "MCF7 cells were treated with .05 mcM doxorubicin/4 h followed by 1 or 10 mcM zoledronic acid/24 h (or the reverse sequence). To study invasion, MCF7 cells were either grown on Transwell membranes...
Source: Women's Health Weekly (2005-11-10)
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