Women's Health Weekly
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Cancer Risk Factors
Polymorphism in 5' flanking region of SMYD3 linked to risk of human cancers
November 24th, 2005
A polymorphism in the 5' flanking region of SMYD3 was linked to the risk of human cancers. "Histone modification is a crucial step in transcriptional regulation, and deregulation of the modification process is important in human carcinogenesis. We previously reported that upregulation of SMYD3, a histone methyltransferase, promoted cell growth in human colorectal and hepatocellular carcinomas," researchers in Japan reported. "Here we report significant associations between homozygosity with respect to an allele with three tandem repeats of a CCGCC unit in the regulatory region of SMYD3 and increased risk of colorectal cancer (p=9.1 x 10-6,...
Source: Women's Health Weekly (2005-11-24)
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