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DNA Research
Anticancer agent EZZ induces cell cycle arrest in S phase by inhibiting DNA replication
November 24th, 2005
The anticancer agent EZZ induces cell cycle arrest in S phase by inhibiting DNA replication. According to a study from South Korea, "Furanosesterterpenes, isolated from a marine sponge Psammocinia sp. have been reported to display significant cytotoxicity to some cancer cell lines. In this study, EZZ, an inseparable 1:1 mixture of (8E,3Z,20Z)-strobilinin and (7E,3Z,20Z)-felixinin, showed significant antiproliferative effect on human cervix carcinoma cell line (HeLa)." "Cell cycle analysis revealed that EZZ could arrest HeLa cells in S phase with a concomitant decrease in the cell population of G1 phase. By using simian virus (SV40) DNA in...
Source: Women's Health Weekly (2005-11-24)
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