Women's Health Weekly
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Genetics & Genomics
Estrogen-metabolizing gene polymorphism associated with breast cancer risk identified
November 24th, 2005
A multigenic study identifies the polymorphisms of estrogen-metabolizing genes that increase breast cancer risk. "Endogenous estrogen plays a very important role in the carcinogenesis and progression of breast cancer. The enzymes involved in the biosynthesis and metabolism of estrogen have been proposed to contribute to this effect," scientists writing in the Chinese Medical Journal report. D.F. Han and colleagues at Wuhan University conducted "a case-control study to investigate the relationship between polymorphisms of genes responsible for estrogen biosynthesis (CYP17, cytochrome P450c17a and CYP19, aromatase cytochrome P450) and estrogen...
Source: Women's Health Weekly (2005-11-24)
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