Women's Health Weekly
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Apoptosis
Xanthohumol induced apoptosis in B-chronic lymphocytic leukemia cells
December 1st, 2005
Xanthohumol (XA) could induce apoptosis in B-chronic lymphocytic leukemia (B-CLL) cells. According to recent research from Belgium, "B-CLL is an indolent lymphoid malignancy with variable prognosis. Adverse prognostic factors comprise treatment resistance, cytogenetics (11q- and 17p-), the presence of unmutated Ig genes, and the more comprehensive activation marker Zap70." "In contrast to diminished sensitivity to chemotherapy, Zap70+ B-CLL cells retain their responsiveness to manipulation of signal transduction and monoclonals. XA has recently been documented to have an impact on breast cancer cell growth and invasiveness in vitro. Based on these...
Source: Women's Health Weekly (2005-12-01)
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