Women's Health Weekly
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Breast Cancer
Differential gene expression occurs after chromosome transfer into breast cancer cells
December 1st, 2005
Research from Germany has chronicled the profile of differentially expressed genes after transfer of chromosome 17 into the breast cancer cell line CAL51. "Previous studies have shown that transfer of chromosome 17 suppresses the tumorigenic phenotype of the breast cancer cell line CAL51, suggesting the presence of putative tumor suppressor genes on this chromosome," wrote C. Klebig and colleagues, Humboldt University. "Suppression subtractive hybridization and oligonucleotide microarray analyses were performed to identify differentially expressed genes in nontumorigenic microcell hybrids, CAL/17-1 and CAL/17-3, when compared with CAL51...
Source: Women's Health Weekly (2005-12-01)
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