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Women's Health Weekly

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Osteoporosis



Postmenopausal osteoporosis risk associated with haplotype in premenopausal women



December 1st, 2005

Postmenopausal osteoporosis risk is associated with a specific haplotype in premenopausal women.

"It is well established that the development of postmenopausal osteoporosis is under genetic influence." Recent research published in the journal Osteoporosis International identified "a synonymous single nucleotide polymorphism (SNP) in exon 8 of estrogen receptor-alpha (ER-alpha) gene in the vicinity of the stop codon (G2014A) that is associated with an increased risk of postmenopausal osteoporosis."

In their study, B. Ongphiphadhanakul and colleagues "attempted to locate SNPs in the 3'-unstranslated region (3'UTR) of the ER alpha gene that are...


Source: Women's Health Weekly (2005-12-01)

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