Women's Health Weekly
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Carcinogenesis
Candidate tumor suppressor gene ZAC involved in etiology of basal cell carcinomas
December 1st, 2005
The candidate tumor suppressor gene ZAC might be involved in the etiology of basal cell carcinomas. "ZAC is a zinc finger transcription factor that induces apoptosis and cell cycle arrest in various cell lines. The corresponding gene is maternally imprinted and localized on chromosome 6q24-q25, a region harboring an unidentified tumor suppressor gene for a variety of solid neoplasms," scientists in France reported. "ZAC expression is lost or down-regulated in some breast, ovary, and pituitary tumors and in an in vitro model of ovary epithelial cell transformation. In the present study, we examined ZAC expression in normal skin and found a high...
Source: Women's Health Weekly (2005-12-01)
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