Women's Health Weekly
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Apoptosis
Apoptosis-related residues in human thymosin beta-10 identified by mutational analysis
December 1st, 2005
Apoptosis-related residues in human thymosin beta-10 (TB10) were identified by mutational analysis. "TB10 is an actin monomer-sequestering peptide that consists of 43 amino acid residues and that tends to form alpha-helical structures. Previously, we showed that the overexpression of TB10 dramatically increases the frequency of apoptosis in human ovarian cancer cells," scientists in South Korea reported. "[The study's aim was] to identify the critical residues responsible for TB10-mediated apoptosis, we used a series of computational methods. First, a three-dimensional structure of human TB10 was constructed using the homology modeling method with...
Source: Women's Health Weekly (2005-12-01)
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