Women's Health Weekly
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Apoptosis
TRAIL-mediated apoptosis enhanced by amiloride
December 1st, 2005
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis was enhanced by amiloride. "TRAIL has been shown to induce apoptosis in numerous transformed cell lines but not in most normal cells. Although this selectivity offers a potential therapeutic application in cancer, not all cancers are sensitive to TRAIL-mediated apoptosis," researchers in the United States reported. "In this study, we observed that amiloride, a current clinically used diuretic drug, which had little or no cytotoxicity, sensitized TRAIL-resistant human prostate adenocarcinoma LNCaP and human ovarian adenocarcinoma SK-OV-3 cells. The TRAIL-mediated...
Source: Women's Health Weekly (2005-12-01)
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