Women's Health Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Women's Health Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Apoptosis
Rho GDP dissociation inhibitor protects cancer cells against apoptosis
December 8th, 2005
According to recently published research from the United States, Rho GDP dissociation inhibitor (RhoGDI) protects cancer cells against drug-induced apoptosis. B.L. Zhang and colleagues, U.S. Food and Drug Administration, wrote: "RhoGDI plays an essential role in control of a variety of cellular functions through interactions with Rho family GTPases, including Rac1, Cdc42, and RhoA. RhoGDI is frequently overexpressed in human tumors and chemoresistant cancer cell lines, raising the possibility that RhoGDI might play a role in the development of drug resistance in cancer cells." "We found that overexpression of RhoGDI increased resistance of cancer...
Source: Women's Health Weekly (2005-12-08)
|
