Women's Health Weekly
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Breast Cancer
Hyaluronan synthase suppression inhibits breast cancer tumorigenesis
December 8th, 2005
According to research from Australia, antisense-mediated suppression of hyaluronan synthase (HAS) 2 inhibits the tumorigenesis and progression of breast cancer. "The progression of several cancers is correlated with the increased synthesis of the glycosaminoglycan, hyaluronan. Hyaluronan is synthesized at the plasma membrane by various isoforms of HAS," wrote L. Udabage and colleagues, Monash University. "The importance of HAS2 expression in highly invasive breast cancer was characterized by the antisense inhibition of HAS2 (ASHAS2). The effect of HAS2 inhibition on cell proliferation, migration, hyaluronan metabolism, and receptor status was...
Source: Women's Health Weekly (2005-12-08)
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