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Breast Cancer Risk Factors

Polymorphism may modify effect of endogenous sex hormone on breast cancer risk

According to researchers in the United states, "Sulfotransferase (SULT) 1A1 is involved in the inactivation and elimination of estrogens and catechol estrogens. A common functional polymorphism (Arg213His) has been linked in our previous study of postmenopausal Caucasian women to an elevated risk of breast cancer and the association appeared to be modified by factors related to high endogenous estrogen exposures."

G. Yang and colleagues wrote, "We further evaluated this polymorphism and levels of BMI and steroid hormones...

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