Women's Health Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Women's Health Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Breast Cancer
Anti-estrogen-resistant breast cancer cells require activated protein kinase B/Akt for growth
December 15th, 2005
Anti-estrogen-resistant human breast cancer cells require activated protein kinase B/Akt for growth. According to recent research from Denmark, "Development of acquired resistance to anti-estrogens is a major clinical problem in endocrine treatment of breast cancer patients. The IGF system plays a profound role in many cancer types, including breast cancer. Thus, overexpression and/or constitutive activation of the IGF-I receptor (IGF-IR) or different components of the IGF-IR signaling pathway have been reported to render breast cancer cells less estrogen dependent and capable of sustaining cell proliferation in the presence of anti-estrogens." "In...
Source: Women's Health Weekly (2005-12-15)
|
