Women's Health Weekly
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Cancer Gene Therapy
HER-2 protein expression can be inhibited in ovarian cancer cells
December 15th, 2005
According to recently published research from the United States, synthetic microRNA (miRNA) and double-stranded RNA (dsRNA) targeting the 3'-untranslated region of HER-2/neu mRNA inhibits HER-2 protein expression in ovarian cancer cells. "miRNA are a class of non-coding RNAs found both in normal tissues and cancer cells. The natural miRNA, which target cancer genes for transcriptional repression, are still unknown." "Approaches for synthetic miRNA design targeting cancer genes have not yet been established. We designed miRNAs targeting the 3' UTR (nt 4350-4372) of HER-2 proto-oncogene," wrote N. Tsuda and colleagues, M.D. Anderson Cancer...
Source: Women's Health Weekly (2005-12-15)
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