Endocrinology
Gonadotropin-releasing hormone analogs resensitize breast cancer cells to tamoxifen
Published in Women's Health Weekly, December 15th, 2005
According to recent research from Germany, "about 50%-64% of human breast cancers express receptors for GnRH-I. Direct antiproliferative effects of analogs of GnRH-I on human breast cancer cell lines have been shown."
"They are at least in part mediated by antagonizing growth promoting effects of estradiol, epidermal growth factor (EGF) or insulin-like growth factor. Recently, expression of a putative receptor for GnRH-II in human tissues was demonstrated. Antiproliferative effects of GnRH-II in human endometrial and ovarian cancer cells were shown not to be...
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