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Environmental Health

Novel HPLC-MS/MS assay reveals low general exposure to bisphenol A in humans

Published in Women's Health Weekly, December 15th, 2005

A novel HPLC-MS/MS assay has been used to show that environmental bisphenol A (BPA) exposure is lower than many scientists had feared.

BPA "is a weak estrogen. Pharmacokinetic studies of BPA have demonstrated a rapid and extensive metabolism of BPA to the nonestrogenic BPA-monoglucuronide (BPA-gluc)," according to toxicologists in Germany.

"Some investigators have reported that BPA was found at parts per billion concentrations in the tissues or urine of humans without known exposure to BPA," noted W. Volkel and colleagues at the University of Wurzburg. In a recent study, they "developed a rapid and sensitive method for the determination of BPA and...

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