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Bone Mineral Density

Polymorphisms of CLCN7 gene contribute to regulation of bone mineral density

According to scientists in Scotland, "The CLCN7 gene is a strong candidate for regulation of BMD, because mutations in CLCN7 cause some forms of osteopetrosis, a disease characterized by impaired osteoclast function and increased BMD. In this study, we sought to determine whether common allelic variation within CLCN7 was associated with BMD in the normal population."

U. Pettersson and colleagues explained, "We conducted mutation screening of the exons and intron-exon boundaries in CLCN7 by DNA sequencing in 50 normal subjects. We conducted an...

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