Women's Health Weekly
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Breast Cancer
ADAM 12-mediated focal adhesion formation is differently regulated by integrins
December 22nd, 2005
According to recent research from Denmark, ADAM 12-mediated focal adhesion formation is differently regulated by beta 1 and beta 3 integrins. C.K. Thodeti and colleagues, University of Copenhagen, wrote, "ADAM12, a disintegrin and metalloprotease, has been demonstrated to be upregulated in human malignant tumors and to accelerate the malignant phenotype in a mouse model for breast cancer." "ADAM12 is a substrate for beta 1 integrins and may affect tumor and stromal cell behavior through its binding to PI integrins." "Here," wrote the researchers, "we report that cells deficient in beta 1 integrin or overexpressing beta 3 integrin...
Source: Women's Health Weekly (2005-12-22)
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