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Cardiovascular Research

Sigma-1/cocaine receptors mediate effects of female sex hormones on endothelin-1 release

According to a report from Germany, "Cardiovascular disease is rare in premenopausal women compared to men. We investigated sex hormone-induced endothelin-1 (ET-1) release and the involvement of classic sex hormone receptors as well as the ability of sigma-1/cocaine receptors to respond to sex hormones."

U. Wilbert-Lampen and colleagues explained, "ET-1 release in the supernatant of endothelial cells was measured after treatment with beta-estradiol, progesterone, testosterone, or combined with their antagonists, and with the sigma-1 receptor ligand...

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