Women's Health Weekly
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Cancer Risk Factors
FASL-844C polymorphism associated with increased risk of cervical cancer
December 22nd, 2005
FASL-844C polymorphism was associated with an increased risk of cervical cancer. "The FAS receptor-ligand system plays a key role in regulating apoptotic cell death, and corruption of this signaling pathway has been shown to participate in tumor-immune escape and carcinogenesis," scientists in the People's Republic of China reported. "We have recently demonstrated (Sun, T., et al. 2004. J. Natl. Cancer Inst. 96:1030-1036; Zhang, X., et al. 2005. J. Med. Genet. 42:479-484) that functional polymorphisms in FAS and FAS ligand (FASL) are associated with susceptibility to lung cancer and esophageal cancer; however, the mechanisms underlying this...
Source: Women's Health Weekly (2005-12-22)
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