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Women's Health Weekly

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Cancer Therapy



Dynamic MRI clarifies the effect of chemotherapy on tumor vascularity



December 22nd, 2005

Dynamic contrast MRI (DCE-MRI) clarifies the effect of chemotherapy on tumor vascularity.

"DCE-MRI is being used increasingly in clinical trials to demonstrate that vascular disruptive and antiangiogenic agents target tumor microcirculation. Significant reductions in DCE-MRI kinetic parameters are seen within 4-24 and 48 h of treatment with vascular disruptive and antiangiogenic agents, respectively," researchers in England report.

"It is important to know whether cytotoxic agents also cause significant acute reductions in these parameters, for reliable interpretation of results. This study investigated changes in transfer constant (K trans) and the...


Source: Women's Health Weekly (2005-12-22)

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