Women's Health Weekly
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Breast Cancer
Cytokines secreted by bone-metastatic breast cancer cells alter f-actin expression pattern
December 29th, 2005
Cytokines secreted by bone-metastatic breast cancer cells alter the expression pattern of f-actin and reduce focal adhesion plaques in osteoblasts through PI3K. According to a study from the United States, "Breast cancer frequently metastasizes to bone, resulting in osteolytic lesions. These lesions, formed by activated osteoclasts, cause pain, an increased susceptibility to fractures, and hypercalcemia." "It has been shown that breast cancer cells communicate with osteoblasts and subsequently stimulate osteoclast activity; however, little research has focused on understanding the interaction between breast cancer cells and ostcoblasts. We recently...
Source: Women's Health Weekly (2005-12-29)
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