Women's Health Weekly
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Breast Cancer
Metalloproteinase inhibition stimulates gene expression in breast cancer cells
December 29th, 2005
According to a study from the United States, tissue inhibitor of metalloproteinases-1 (TIMP-1) stimulates gene expression in MDA-MB-435 human breast cancer cells by means of its ability to inhibit metalloproteinases (MPs). "TIMP-1 is a widely expressed, secreted protein that functions primarily to inhibit members of a large family of MPs. Because of the ability of TIMP-1 to inhibit MPs, it functions in many of the same pathophysiological processes as these enzymes, e.g. wound healing, ovulation, angiogenesis, and cancer cell metastasis," wrote J.F. Porter and colleagues, Rutgers State University. "TIMP-1 can also stimulate proliferation (H-3-Thy...
Source: Women's Health Weekly (2005-12-29)
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