Women's Health Weekly
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Breast Cancer
Mice lacking cyclooxygenase-2 capacity have reduced mammary tumorigenesis and angiogenesis
December 29th, 2005
Mice lacking cyclooxygenase-2 (Cox-2) capacity have reduced mammary tumorigenesis and angiogenesis. "The inducible prostaglandin synthase Cox-2 is overexpressed in approximately 40% of human breast cancers and at higher frequencies in preinvasive ductal carcinoma in situ (DCIS). Cox-2 expression is particularly associated with overexpression of human epidermal growth factor receptor 2 (HER2/neu)," investigators in the United States report. "To definitively interrogate the role of Cox-2 in mammary neoplasia, we have used a genetic approach, crossing Cox-2-deficient mice with a HER2/neu transgenic strain, MMTV/NDL. At 20 weeks of age, mammary glands...
Source: Women's Health Weekly (2005-12-29)
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