Women's Health Weekly
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Breast Cancer
Microarray CGH reveals genetic regulators of tumorigenic RTK signaling
December 29th, 2005
Microarray CGH analysis has been used to identify genes and gene loci involved in regulating tumorigenic RTK signaling in breast epithelial cells. "Receptor tyrosine kinase (RTK) signaling plays a key role in the development of breast cancer. Defining the genes and pathways in the RTK signaling network that are important regulators of tumorigenesis in vivo will unveil potential candidates for targeted therapeutics," researchers in the United States argued. "To this end," J.G. Hodgson and colleagues at the University of California-San Francisco "used microarray comparative genomic hybridization to identify and compare copy number aberrations in five...
Source: Women's Health Weekly (2005-12-29)
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