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Women's Health Weekly

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Breast Cancer Risk Factors



PvuII polymorphism in estrogen receptor-alpha increases breast cancer risk



December 29th, 2005

The presence of the PvuII polymorphism in the estrogen receptor-alpha increases breast cancer risk in postmenopausal women.

In a recent study from the Netherlands, scientists "aimed to investigate whether the PvuII, XbaI and B-variant polymorphisms in the estrogen receptor alpha gene (ER-alpha) are associated with an increased risk of breast cancer in postmenopausal women, and whether the effect of high estradiol (E2) levels on breast cancer risk is altered by these polymorphisms."

N.C. Onland-Moret and colleagues explained, "The selection of these polymorphisms was based on previously published associations with osteoporosis and spontaneous...


Source: Women's Health Weekly (2005-12-29)

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