Women's Health Weekly
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Breast Cancer Therapy
Progesterone stimulates epidermal growth factor-induced breast cancer proliferation
December 29th, 2005
Progesterone stimulates epidermal growth factor-induced breast cancer proliferation. According to a study from Chile, "progesterone in hormone replacement therapy (HRT) preparations increases, while hysterectomy greatly reduces, the incidence of breast cancer. Cross-talk between the progesterone and growth factor signaling pathways occurs at multiple levels and this may be a key factor in breast cancer survival and progression." "To test this hypothesis, we characterized the effect of progesterone pre-treatment on the sensitization of the EGF signaling pathway to EGF in the breast cancer cell line ZR-75. For the first time in ZR-75 cells and in...
Source: Women's Health Weekly (2005-12-29)
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