Women's Health Weekly
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Stroke
Estrogens may play key role as multiple targeting protectants against ischemic stroke
December 29th, 2005
Estrogens may play key role as multiple targeting protectants against ischemic stroke. According to a study from the United States, "Disruption of blood-brain barrier (BBB), mediated through matrix metalloproteinases (MMPs), is a critical event during cerebral ischemia. While neuroprotective effects of estrogens have been well established in ischemic stroke models, the effects of estrogens on BBB integrity remain to be elucidated." "In the present study, we determined effects of 17 beta-estradiol (E2) on BBB disruption induced by transient focal cerebral ischemia and its effects on MMP2 and MMP9 activation. Transient cerebral ischemia was induced by...
Source: Women's Health Weekly (2005-12-29)
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